The leading industries are machine building, chemical industry, oil chemical, metallurgy, timber, and pulp and paper industry. Oil and chemical industries are provided by local supply.

Perm region is the leader in production of gas compressor units, fiber optical and navigation systems, rocket fuel, magnesium and titanium alloys. The only Russia's enterprise producing titanium sponge is located in Perm region. Metallurgy is enterprises process ferrous and nonferrous metals and rare earth metals as well as powder metallurgy. Nonferrous metallurgy is based on ore processing Verkhnekamskoye potash deposit containing magnesium and rare metals.

The share of industry in GRP is over 40% (average in Russia is 30%).
Exporter of the Year