Perm region is famous for its rich cultural heritage, theaters and museums. There are over 10 professional performance companies, 47 museums. There is a circus, philarmony and planetarium in Perm.

There are many theaters in Perm, including the Perm Opera and Ballet Theater, the Perm Academic Theater, the Puppet Theater, the Theater for Young Spectators, the Theater "Near Bridge", and others. There are academic theaters in Lysva, Berezniki, Chaikovsky and Kudymkar.  The Perm Opera and Ballet Theater is one of the oldest theaters in Russia with world famous ballet company. Perm Choreographic College graduates perform in the theater.

The region's most famous museum is Perm Art Gallery which is home to renowned collection of Perm wooded sculpture. The Gallery stores one of the largest collections of Russian icon masterpieces (Stroganoff's icon school) and original artworks by Repin, Levitan, Savrasov and Serov.